PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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Ethyl 3-aminopropanoate
0 ImagesCat. No.: HY-W243057CAS No.: 924-73-2
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Ethyl 3-(4-(hydroxymethyl)phenyl)propanoate
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Ethyl 5-bromo-4-oxopentanoate
0 ImagesCat. No.: HY-W320948CAS No.: 14594-25-3
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19-Hydroxynonadecanoic acid
0 ImagesCat. No.: HY-W614815CAS No.: 22438-61-5
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Boc-PEG3-O-methyl acetate
0 ImagesCat. No.: HY-W567494CAS No.: 2100306-59-8
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Methyl 4-((tert-butoxycarbonyl)amino)butanoate
0 ImagesCat. No.: HY-W101725CAS No.: 85909-04-2
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Tert-butyl (3-cyanopropyl)(methyl)carbamate
0 ImagesCat. No.: HY-W395458CAS No.: 1379225-92-9
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3-[Benzyl(methyl)amino]propanoic acid
![3-[Benzyl(methyl)amino]propanoic acid](https://file.medchemexpress.com/product_pic/hy-w151576.gif "Click to View 3-[Benzyl(methyl)amino]propanoic acid Product Detail")
0 ImagesCat. No.: HY-W151576CAS No.: 149692-49-9
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H2N-PEG2-CH2COOtBu hydrochloride
0 ImagesCat. No.: HY-135927ACAS No.: 2098500-69-5
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m-PEG12-Br
0 ImagesCat. No.: HY-141378CAS No.: 1620461-89-3
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2-(4-(2-Aminoethyl)piperazin-1-yl)ethan-1-ol
0 ImagesCat. No.: HY-W318996CAS No.: 20542-08-9
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Hydroxy-PEG7-CH2-Boc
0 ImagesCat. No.: HY-133310CAS No.: 2378049-28-4Synonyms: HO-PEG7-CH2COOtBu
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7-((Tert-butyldimethylsilyl)oxy)heptan-1-ol
0 ImagesCat. No.: HY-W970096CAS No.: 126696-08-0
![Boc-PIP-Me-CH2-2,7-diazaspiro[3.5]nonane](https://file.medchemexpress.com/product_pic/hy-168075.gif "Click to View Boc-PIP-Me-CH2-2,7-diazaspiro[3.5]nonane Product Detail")
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N-(m-PEG4)-N'-(4-Hydroxycyclohexyl-1-amido-PEG4)-Cy5
0 ImagesCat. No.: HY-141075CAS No.: 2107273-72-1
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tert-Butyl (3-aminopropoxy)carbamate
0 ImagesCat. No.: HY-W419952CAS No.: 228245-16-7
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Benzyl 2-cyanoacetate
0 ImagesCat. No.: HY-W095744CAS No.: 14447-18-8Synonyms: Benzyl cyanoacetate
